Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice
نویسندگان
چکیده
منابع مشابه
Gonadotropin stimulation contributes to an increased incidence of epimutations in ICSI-derived mice.
We previously demonstrated that intracytoplasmic sperm injection (ICSI), a type of assisted reproductive technology (ART), can induce epimutations and/or epimutant phenotypes in somatic tissues of adult mice produced by this method. In the present study, we compared the occurrence of epimutations in mice produced by natural conception, ICSI and somatic cell nuclear transfer. Surprisingly, we ob...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2012
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/dds287